A Transport for London (TfL) spokesman said a fire alert had shut down the station.
Meanwhile, London Fire Brigade confirmed that the evacuation was triggered by a fire alarm that had been activated.
British transport police said the evacuation was a precautionary measure.
They said: “British transport police have been called this morning on the Elizabeth line to Paddington station following a report of a fire alarm.
READ MORE
“The station was evacuated as a precaution. The London Fire Brigade attended, the alarm was deemed to have been triggered by accident. Since then, the station has reopened.”
The images showed crowds leaving the station and shutters blocking the line to passengers.
The incident, which lasted about half an hour, caused small disruptions in people’s movements.
Dave Shuttleworth
One person wrote on Twitter: “Fantastic trip on the #Elizabeth line. It arrived in Paddington just as the station was being evacuated, but it must have been teething problems. I can’t wait for Bond Street to be as close as possible. the office”.
Another said the incident had added an additional 15 minutes to his morning trip.
They wrote: “I tried to reduce my commute by going to Paddington instead of Marylebone and taking the Elizabeth line.
“The Elizabeth to Paddington line is evacuated and I end up on the same bus I always get, with an extra 15 minutes added to my trip. Fair enough.”
Others have seen the positive side, saying, “At least the evacuation process works! Good practice and luckily it was a false alarm! “
Meanwhile, another person added, “Never change, London.”
Hundreds of people had gathered at the station to have the opportunity to board the first train leaving for Abbey Wood shortly after 6.30am.