Washington, DC – June 11, 2022 – T cell testing using a commercial T cell test, QuantiFERON SARS-CoV-2 RUO, provides information on the immune response to infection and vaccination of patients with COVID-19 and suggests that age and time since infection are important factors related to the magnitude of cell-mediated immune responses (MICs) to COVID-19. The findings are presented at ASM Microbe 2022, the annual meeting of the American Society of Microbiology.
The findings of the new findings are based on evidence from an observational clinical study with human subjects conducted between June 2021 and February 2022 in the United States and the Netherlands. SARS-CoV-2 T-cell testing can provide researchers and physicians with information about a person’s ability to fight future COVID-19 infection. QuantiFERON SARS-CoV-2 RUO, a commercial T-cell test, detected T-cell-mediated immune responses in 80% of subjects in clinical trials who completed COVID-19 vaccination at 24 previous weeks (6 months).
When assessing which factors may be associated with poor T-cell responses observed after vaccination, only increasing age is significantly associated with a poor T-cell response. time since vaccination, vaccine type received, or gender not associated with T cell response. In subjects who had been infected with SARS-CoV-2, QuantiFERON SARS-CoV-2 RUO detected T cell responses in 74% of subjects who had been infected in the previous 24 weeks. The only factor associated with poor T-cell responses after infection was the time elapsed after infection.
“This study reinforces current knowledge linking age and time of infection with decreased immunity to SARS-CoV-2, which may in turn contribute to increased susceptibility to infection and subsequent disease.” said Robin Uchiyama, head of clinical study, Clinical Affairs. at QIAGEN and the lead author of the study. “This work highlights the importance of T-cell testing and the implementation of strong preventive measures against infection, such as vaccination, booster and masking, even after vaccination in older adults or after vaccination. infection “.
The QIAGEN-funded work was led by the QIAGEN Clinical Affairs Group based in Germantown, Maryland, and will be presented at ASM Microbe in Washington, DC on Saturday, June 11, 2022.
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ASM Microbe is the annual meeting of the American Society of Microbiology, held June 9-13, 2022 in Washington, DC
The American Society of Microbiology is one of the largest professional societies dedicated to the life sciences and is made up of 30,000 scientists and health professionals. ASM’s mission is to promote and advance the microbial sciences.
ASM advances microbial science through lectures, publications, certifications, educational opportunities, and advocacy efforts. Improves laboratory capacity worldwide through training and resources. It provides a network for scientists in the academic, industrial and clinical fields. In addition, ASM promotes a deeper understanding of microbial science to diverse audiences.
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