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Researchers at Baylor and Stanford universities say they have taken an important step in condensing some of the benefits of exercise into a simple pill.
Researchers, Baylor Professor of Pediatrics, Dr. Yong Xu, and Stanford Assistant Professor of Pathology, Dr. Jonathan Long, say they have identified a molecule produced in the blood during exercise that has successfully reduced intake. of food and obesity in mice, according to researchers. Baylor School of Medicine.
“Regular exercise has been shown to help you lose weight, regulate appetite and improve your metabolic profile, especially for overweight and obese people,” Xu said. “If we can understand the mechanism by which exercise triggers these benefits, then we are closer to helping many people improve their health.”
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FILE – Anandi Cade lifts weights on Fitness SF at Fillmore Street in San Francisco, December 29, 2021. (Scott Strazzante / The San Francisco Chronicle via Getty Images)
“We wanted to understand how exercise works at the molecular level so we can capture some of its benefits,” Long added. “For example, older or frail people who can’t get enough exercise may one day benefit from taking a medication that can help curb osteoporosis, heart disease, or other conditions.”
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The pair of researchers identified an amino acid called Lac-Phe. When they gave doses of the amino acid to mice that were fed a high-fat diet, they observed a 50% decrease in food intake over the next 12 hours, according to Baylor.
Researchers also found that humans, and even racehorses, produce the same amino acid when subjected to intense physical activity.
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“Our next steps include finding out more about how Lac-Phe mediates its effects on the body, including the brain,” Xu told Baylor. “Our goal is to learn how to modulate this exercise pathway for therapeutic interventions.”