Ontario says its total number of confirmed monkeypox cases rose by 58 since Tuesday, with hospitals admitting a second infected person to an ICU.
The number of confirmed cases has increased by 20% since Tuesday.
There are now 288 confirmed cases of infection in Ontario, up from 230 on July 19, 156 on July 14 and 133 on July 11.
Public Health Ontario says there is only one confirmed case left in a woman, with the remaining cases in men.
More than 76 percent (220) of cases involve Toronto residents.
There are still nine probable cases under investigation, including two in adult women.
Since Tuesday, the health authorities say that a second person admitted to the hospital for monkey pox has required transfer to the ICU.
So far, there have been a total of nine hospitalizations and two ICU admissions related to monkeypox in Ontario.
Across the province, Hamilton reports seven cases in total, Halton reports eight, Middlesex-London has reported 10 so far and Ottawa has reported 21.
No deaths have been reported in Ontario.
The most common symptoms include rash, oral/genital lesions, swollen lymph nodes, headache, fever, chills, myalgia, and fatigue.
Monkeypox is usually spread through close and sustained contact between people who breathe, talk, cough or sneeze.
It can also be spread by skin-to-skin contact with rashes or body fluids, and it can also remain on items such as clothing or bedding that have come into contact with an infected person.
Symptoms may appear five to 21 days after exposure.
Infected people can remain contagious through skin contact for up to four weeks.
Ontario is now testing anyone who presents to a health care provider or emergency room with an “unexplained acute rash or injury.”
Federal guidelines state that the smallpox vaccine is most effective if given within four days of exposure to a case, but may help if given up to 14 days after exposure.
The City of Toronto continues to offer Imvamune smallpox vaccine to people considered at high risk of exposure.
There is also a therapeutic known as TPoxx that has proven helpful in cases where patients have suffered serious complications from infection.
The World Health Organization (WHO) now says it is aware of 15,734 confirmed cases of monkeypox in 59 countries around the world, including three deaths.
The Public Health Agency of Canada (PHAC) says it is aware of 681 confirmed cases across Canada, most in Ontario and Quebec.